The 2025 NCAA Final Four will take place on Saturday from the Alamodome in San Antonio.

Duke and Houston will be the nightcap after Florida and Auburn begin the action.

The Blue Devils are the favorite to win it all this year but run into Houston and its stingy defense — and a team that can light it up from deep.

When preparing for this game, here are a few bets that you might consider.

Spread: Houston +6

It feels like Duke is going to win this game. Maybe it is just because of the year that the Blue Devils have had but there is something special about this team. The question is, if Duke wins, by how many? Houston has the ability on both ends to stay in this game, not to mention the experience led by LJ Cryer. Duke has the star power with Cooper Flagg and Kon Kneuppel but there is no reason that Houston can’t hang around and make this a close game. The only concern is free throws and fouls at the end of games, which if you know college hoops, that is always the concern when betting.

Total: Over 137

Houston is the No. 1 scoring defense in the nation. Duke is right up there as well. This does not feel like an under and Vegas is really trying to get you to take one with this number. This is not normal territory for Houston. Duke’s offensive game plan has bee difficult to stop. Both teams can knock down three-point shots. This feels like a trick over when it is all said and done.

Prop: Sion James 2+ Three-Pointers

This is not a proper that might be at the top of your mind but when you consider Houston’s defense, it might be possible. The Cougars are going to key in on there scorers within the offense. James has a tendency to get lost on the perimeter when Flagg and Kneuppel get to the basket. Proctor has also shot it well in recent weeks. Enter James. He does not shoot many but is a 42% shooter when he gets his opportunities. There should be plenty out there on Saturday night as he wanders around the perimeter and finds his open spot from deep.